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http://www.hwbf.org/ota/am/ota98/otapa/OTA98502.htm
OTA poster/paper 1998
The etiology of the radiographic findings of osteolysis and periosteal reaction is not specifically known, but the presence of corrosion products at the taper junctions suggests particulate debris as a factor. There was an association between the radiographic abnormalities (osteolysis and periosteal reaction) and thigh pain and elevated serum chromium levels, indicating that these findings have clinical significance. Serial follow-up of this cohort of patients is indicated and is currently underway.
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