Acetaminophen for osteoarthritis (Cochrane Review) Towheed TE, Maxwell L, Judd MG, Catton M, Hochberg MC, Wells G The Cochrane Database of Systematic Reviews 2006, Issue 1. Art. No.: CD004257.pub2. Authors' conclusions: The evidence to date suggests that NSAIDs are superior to acetaminophen for improving knee and hip pain in people with OA. The size of the treatment effect was modest, and the median trial duration was only six weeks, therefore, additional considerations need to be factored in when making the decision between using acetaminophen or NSAIDs. In OA subjects with moderate-to-severe levels of pain, NSAIDs appear to be more effective than acetaminophen. Highly Reputable

Other surgical techniques for osteoarthritis Best Practice & Research Clinical Rheumatology Volume 20, Issue 1 , February 2006, Pages 155-176 Osteoarthritis Neil A. Segal MD, , Assistant Professor and Staff Physiatrist, Joseph A. Buckwalter MD, Professor and Chair and Annunziato Amendola MD, Professor Department of Orthopedics and Rehabilitation, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242-1088, USA Available online 14 February 2006. Prior to the need for arthroplasty, there are numerous surgical options for management of osteoarthritis. This chapter is aimed at addressing the current state of knowledge and practice regarding: (1) arthroscopic lavage and debridement; (2) articular surface stimulation by means of penetration or microfracture; (3) high tibial osteotomies; (4) preventative ligament stabilization and joint distraction; and (5) transplantation of soft tissue, osteochondral, chondrocyte and matrix implantation as well as use of growth factors. Evidence is reviewed regarding the outcomes and indications for each of these operations, and where evidence is lacking, needs for further research are indicated. Future directions building upon promising early results of articular surface regeneration are also described.