Summary: Antibiotics are effective in preventing early infection in open fractures of the limbs Wound and bone infections are common complications following open fractures of the limbs. For more than 20 years, in developed countries, the use of antibiotics has been a part of a standard management protocol that also includes irrigation, surgical debridement, and stabilisation when indicated. The review of trials found that antibiotics are effective in decreasing the incidence of wound infections, as compared to no antibiotics or placebo. No studies on bone infection or long-term morbidity were identified. (Cochrane Review)
Gosselin RA, Roberts I, Gillespie WJ. Antibiotics for preventing infection in open limb fractures. Cochrane Database of Systematic Reviews 2004, Issue 1. Art. No.: CD003764.

From Journal RCSE

Wheeless' Textbook of Orthopaedics

SIGN Publication No. 45 ISBN 1899893 22 9 Published July 2000

Review of post-op wound infections Nigerian Journal of Surgical Research 6(1-2)2004

A case of Total Hip Arthroplasty infection with Staphylococcus aureus co-infected with Salmonella choleraesuis was treated with two-stage exchange and administration of vancomycin and ciprofloxacin. No signs of re-infection have appeared 14 months after surgery. Cases of Salmonella infection of hip prostheses are quite rare, with only a handful of reports in the literature.

In this Review we deal with Surgical Infections requiring surgical intevention and in particular, soft tissue infections.
Soft-tissue infections: Abscess, Cellulitis, Ulcers, Tropical Pyomyositis, Necrotizing Fasciitis, Myonecrosis/Gas Gangrene and Tetanus