Connective Tissue Neoplasms (Subscribe)


Categories

Chondroblastoma (7)
A usually benign tumor composed of cells which arise from chondroblasts or their precursors and which tend to differentiate into cartilage cells. It occurs primarily in the epiphyses of adolescents. It is relatively rare and represents less than 2% of all primary bone tumors. The peak incidence is in the second decade of life; it is about twice as common in males as in females. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1846) OCOSH Code C04.557.450.565.250_BD_BN_CTS_CT_CB
Chondroma (12)
A benign neoplasm derived from mesodermal cells that form cartilage. It may remain within the substance of a cartilage or bone (true chondroma or enchondroma) or may develop on the surface of a cartilage (ecchondroma or ecchondrosis). (Dorland, 27th ed; Stedman, 25th ed) OCOSH Code C04.557.450.565.265_BD_BN_CTS_CT_C
Chondrosarcoma (26)
A slowly growing malignant neoplasm derived from cartilage cells, occurring most frequently in pelvic bones or near the ends of long bones, in middle-aged and old people. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion or in patients with ENCHONDROMATOSIS. (Stedman, 25th ed) OCOSH Code C04.557.450.565.280_BD_BN_CTS_CT_CS
Clear Cell Sarcoma (6)
A sarcoma of young, often female, adults of the lower extremities and acral regions, intimately bound to tendons as circumscribed but unencapsulated melanin-bearing tumors of neuroectodermal origin. An ultrastructural finding simulates flattened and curved barrel staves, corresponding to the internal structures of premelanosomes. There is a 45-60% mortality in clear cell sarcoma. (Segen, Dictionary of Modern Medicine, 1992) OCOSH Code C04.557.450.565.800_BD_BN_CTS_CT_CCS
Fibrous Tissue Neoplasms (85)
Neoplasms composed of fibrous tissue, the ordinary connective tissue of the body, made up largely of yellow or white fibers. The concept does not refer to neoplasms located in fibrous tissue. OCOSH Code C04.557.450.565.590_BD_BN_CTS_CT_FT
Haemangioma (6)
Haemangioma of Soft Tissue
Myxoma (10)
A benign neoplasm derived from connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix, thereby resembling primitive mesenchymal tissue. It occurs frequently intramuscularly where it may be mistaken for a sarcoma. OCOSH Code C04.557.450.565.550_BD_BN_CTS_CT_MX
Myxosarcoma (4)
A sarcoma, usually a liposarcoma or malignant fibrous histiocytoma, with an abundant component of myxoid tissue resembling primitive mesenchyme containing connective tissue mucin. (Stedman, 25th ed) OCOSH Code C04.557.450.565.560_BD_BN_CTS_CT_MXS
Small Cell Sarcoma (14)
A sarcoma characterized by the presence of small cells, cells measuring 9-14 micrometers with a faint or indistinct rim of cytoplasm and an oval-to-elongated nucleus with relatively dense chromatin. (From Segen, Dictionary of Modern Medicine, 1992) OCOSH Code C04.557.450.565.825_BD_BN_CTS_CT_SCS
Synovial Sarcoma (20)
A malignant neoplasm arising from tenosynovial tissue of the joints and in synovial cells of tendons and bursae. The legs are the most common site, but the tumor can occur in the abdominal wall and other trunk muscles. There are two recognized types: the monophasic (characterized by sheaths of monotonous spindle cells) and the biphasic (characterized by slit-like spaces or clefts within the tumor, lined by cuboidal or tall columnar epithelial cells). These sarcomas occur most commonly in the second and fourth decades of life. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1363) OCOSH Code C04.557.450.565.835_BD_BN_CTS_CT_SS

Links

Epithelioid Sarcoma Wheeless

http://www.wheelessonline.com/ortho/epithelioid_sarcoma

Discussion: - slow growing malignant soft tissue tumor, usually occuring in adults; - "pseudocapsule" or poorly circumscribed mass often attached to tendons, tendon sheath, or joint capsule

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Malignant Melanoma Wheeless

http://www.wheelessonline.com/ortho/malignant_melanoma

Prognosis: - prognosis of malignant melanoma worsens w/ increasing tumor thickness and also appears to be related to tumor site, age, and sex; - lesions on the scalp, hands, and feet, particularly in older pts and males, all have a poorer prognosis; - tumor thickness & 5 year survival rate: - tumor thickness <0.75 mm have> 95% survival rate; - tumor thickness> 4 mm have <50% surviva ratel; - w/ nodal metastasis five-year survival rate declines to 36%; - w/ metastases survival is <5 %; - lymph nodes and lymphatic mapping: - useful for identifying metastasis to the sentinel lymph node; - observation that the classic lymph node dissection would not necessarily identify metastasis to the SLN (which was the case in 10/12 patients in the study by Joseph et al 1999; - in contrast, patients w/ a negative SLN can be spared the morbidity of a complete lymph node dissection

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Squamous Cell Carcinoma

http://www.wheelessonline.com/ortho/squamous_cell_carcinoma

Discussion: - squamous cell carcinoma: this tumor in the hand requires aggressive treatment (usually amputation); - is the most frequent primary malignancy of the hand; - recurrence rates are high (22%), and therefore radical surgical resection is recommended; - most cases of recurrence (67%) are associated w/ metastatic spread; - therefore lymphadenectomy is recommended, eventhough lymph nodes may or may not be palpated;

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