Hypophosphatemic osteomalacia with plantar neurilemoma. A review of the literature (100 cases).
Crouzet, J : Mimoune, H : Beraneck, L : Juan, L H
Rev-Rhum-Engl-Ed. 1995 Jun; 62(6): 463-6
Abstract
A case of hypophosphatemic osteomalacia with recovery after removal of a plantar neurilemoma is reported. One hundred cases of osteomalacia with a connective tissue tumor were found in the medical literature. Both sexes and all age groups were affected. Patients often had severe osteomalacia with decreased serum 1,25 (OH)2 vitamin D and phosphate levels and renal phosphate wasting. These abnormalities resolved immediately after complete excision of the tumor, which was often a small lesion found after the diagnosis of osteomalacia. Of the 100 tumors, 87 were benign and half were vascular (e.g., hemangiopericytoma, hemangioma, angiofibroma). A large number of tumors could not be readily classified because they contained vascular structures, giant cells, spindle-shaped cells, and cartilage. Many other histologic variants were observed, including giant cell tumors, nonossifying fibromas, cartilaginous tumors, and osteosarcomas. The tumor was usually located in a limb, generally a lower limb, and was skeletal in nearly half the cases. The tumors produced one or more substances with a capacity for blocking intracellular phosphate transfer and inhibiting renal tube 1 alpha hydroxylase. The link between these two abnormalities remains unclear.
34 refs.

- is a type of metabolic bone disease in which the essential problem is a lack of available calcium or phosphorus (or both) for mineralization of newly formed osteoid; - children w/ rickets & adults w/ osteomalacia present w/ similar findings; Wheeless' Textbook of Orthopaedics

Osteomalacia is characterized by incomplete mineralization of normal osteoid tissue following closure of the growth plates. Osteomalacia may be part of the spectrum of osseous abnormalities that can be observed in patients with chronic renal insufficiency. This condition is referred to as renal osteodystrophy.

"A condition marked by softening of the bones (due to impaired mineralization, with excess accumulation of osteoid), with pain, tenderness, muscular weakness, anorexia, and loss of weight, resulting from deficiency of vitamin D and calcium. (Dorland, 27th ed)" Source: Medical Subject Headings, 2007_2006_08_08 "inadequate or delayed mineralization of osteoid in mature cortical and spongy bone." Source: CRISP Thesaurus, 2006 "A metabolic bone disease that results from either a deficiency in vitamin D, or an abnormality in the metabolism of vitamin D, or a deficiency of calcium in the diet. The most common symptoms are bone pain and muscle weakness. When it occurs in children it is commonly referred to as rickets. (Diagnostic Surgical Pathology, 3rd ed.) --2003" Source: National Cancer Institute Thesaurus, 2006_03D

Radiology case 448-571

osteomalacia