Previous
Hypophosphatemic osteomalacia with plantar neurilemoma (Visit this link)
Hypophosphatemic osteomalacia with plantar neurilemoma. A review of the literature
(100 cases).
Crouzet, J : Mimoune, H : Beraneck, L : Juan, L H
Rev-Rhum-Engl-Ed. 1995 Jun; 62(6): 463-6
Abstract
A case of hypophosphatemic osteomalacia with recovery after removal of a plantar
neurilemoma is reported. One hundred cases of osteomalacia with a connective tissue tumor
were found in the medical literature. Both sexes and all age groups were affected.
Patients often had severe osteomalacia with decreased serum 1,25 (OH)2 vitamin D and
phosphate levels and renal phosphate wasting. These abnormalities resolved immediately
after complete excision of the tumor, which was often a small lesion found after the
diagnosis of osteomalacia. Of the 100 tumors, 87 were benign and half were vascular (e.g.,
hemangiopericytoma, hemangioma, angiofibroma). A large number of tumors could not be
readily classified because they contained vascular structures, giant cells, spindle-shaped
cells, and cartilage. Many other histologic variants were observed, including giant cell
tumors, nonossifying fibromas, cartilaginous tumors, and osteosarcomas. The tumor was
usually located in a limb, generally a lower limb, and was skeletal in nearly half the
cases. The tumors produced one or more substances with a capacity for blocking
intracellular phosphate transfer and inhibiting renal tube 1 alpha hydroxylase. The link
between these two abnormalities remains unclear.
34 refs.
Submitted by: admin
Hits: 16
Added: Tue Jul 10 2007
